Localization of multifocal electroretinogram abnormalities to the lesion site: findings in a family with Best disease.
نویسندگان
چکیده
OBJECTIVE To determine the association between multifocal electroretinogram (mfERG) abnormalities and macular lesions, as shown by retinal photography and optical coherence tomography (OCT), in a 3-generation family with vitelliform macular dystrophy. METHODS Five family members were examined using OCT, mfERG, and retinal photography. To localize mfERG abnormalities in relation to retinal findings, we overlaid the mfERG trace arrays on the retinal images and aligned the mfERGs and OCT images in the 180 degrees meridian. RESULTS Family members had typical macular lesions, normal full-field ERGs, and reduced electro-oculogram light-dark ratios. The OCT images demonstrated variable lesion severity. Some individuals with good vision and normal-appearing fundi showed OCT abnormalities of the choroid and retinal pigment epithelium. The overlay technique revealed that the depressed mfERGs corresponded with the lesions detected by OCT and retinal photography. The latencies of mfERG components in the 2 central stimulus rings in our patients were often prolonged. CONCLUSIONS The mfERG abnormalities matched the localization of the macular lesions in our patients. The latencies of the mfERG N1 and P1 components in the first 2 concentric stimulus rings were often significantly (>2 SDs) delayed, an observation that has not been previously reported, to our knowledge.
منابع مشابه
Multifocal Malignant Melanoma of Female Ge-nital Tract
A 75-year–old patient was referred with vaginal bleeding. Her physical exam showed two flat dark plaques on the posterior fourchette, mostly on left lateral side of the vulva. A black soft mucosal nodule was present on the left lateral side of upper vagina, and a polypoid ulcerative cervical lesion extended into the right parametrium. Cervical and vaginal biopsies were in favor of malignant mel...
متن کاملA Case Report of Multifocal Epithelial Hyperplasia (Heck's Disease) Treated with CO2 Laser
Focal epithelial hyperplasia or Heck’s disease is a rare benign lesion of oral mucosa caused by human papilloma virus especially subtypes 13 and 32. The disease is predominantly found in children and adolescents with indigenous heritage. This paper reports a unique case of Heck's disease in an 11-year-old Iranian girl with multiple, bilateral and elevated lesions on the buccal and labial mucosa...
متن کاملMorphology and functional characteristics in adult vitelliform macular dystrophy.
PURPOSE Detailed morphologic and functional evaluation of adult vitelliform macular dystrophy (AVMD). METHODS The records of 61 consecutive AVMD patients (inclusion criterion: vitelliform lesion smaller than one disk diameter at least in one eye) were evaluated retrospectively regarding visual acuity, color vision, perimetry, retinal pigment epithelium (RPE) autofluorescence, fluorescein angi...
متن کاملMultifocal Primary Non- Hodgkin’s Lymphoma of the Oral Cavity: Report of Three Cases and Review of the Literature
Objective: Oral non- Hodgkin’s lymphoma (NHL) is a relatively rare neoplasm that may develop in the soft tissues or jaw bones, with or without node or marrow involvement. Oral lymphomas are often difficult to diagnose as there are no characteristic clinical features and usually appear as non-tender swellings. Case: We describe clinical, radiographic, histopathological and immunohistochemica...
متن کاملPolyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era
Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous sy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Archives of ophthalmology
دوره 124 11 شماره
صفحات -
تاریخ انتشار 2006